Top 10 BEST & WORST Supplements to SLOW Aging

Why You’re Wasting Money on These Overrated Aging Products

Author

My Longevity Experiment
January 14, 2025

Best and Worst Supplements to Slow Aging: Insights from Dr. Tim Pearce and Dr. Nichola Conlon

In a detailed review of the top supplements for slowing the aging process, Dr. Tim Pearce and Dr. Nichola Conlon explored a range of compounds, providing a comprehensive analysis of their benefits and drawbacks. Their evaluation is based on emerging evidence, personal insights, and a scoring system designed to rank each supplement's potential to combat aging.

Creatine: A High-Scorer in Longevity Support
Creatine was highlighted as a top choice due to its role in supporting muscle growth and improving cellular energy. Emerging evidence suggests it may play a role in promoting longevity by enhancing muscle function. Dr. Pearce and Dr. Conlon rated creatine at 9/10, a score many would agree reflects its potential.

Omega-3 Oils: The Gold Standard
Omega-3 fatty acids, widely recognized for their health benefits, were given a perfect score of 10/10. These oils are known to reduce inflammation, lower triglycerides, and improve cardiovascular health—key factors in aging-related health issues.

Vitamin D and Vitamin K2: The Perfect Pair
Vitamin D supports immune function and calcium absorption, while Vitamin K2 ensures calcium is directed to bones rather than arteries, preventing arterial calcification. Together, these vitamins earned a combined score of 10/10, reflecting their critical roles in overall health and longevity.

Probiotics: A Mixed Review
Probiotics promote gut microbiome diversity, which is linked to reduced inflammation and improved longevity. However, their effectiveness can vary depending on the strain and the individual’s gut health. Probiotics received a 7/10, reflecting their potential benefits but also their limitations.

GlyNAC: A Powerful Antioxidant Combination
GlyNAC, a combination of N-Acetyl Cysteine (NAC) and glycine, supports the production of glutathione, the body’s master antioxidant. This supplement was rated 9/10, although some experts might argue that this score is slightly generous, given its more pronounced effects in older individuals.

Trimethylglycine (TMG): Support for Methylation
TMG supports methylation, particularly in individuals taking NAD supplements, helping to prevent methyl donor depletion. However, it may not be necessary for those without methylation issues. TMG received a score of 5/10, though some believe it deserves a higher rating in specific contexts.

Turmeric and Curcumin: Potent but Limited
Curcumin, the active ingredient in turmeric, offers powerful anti-inflammatory properties. However, its low bioavailability requires high doses or enhanced formulations for effectiveness. Despite its potential, curcumin received a low score of 2/10 due to these limitations.

NMN (Nicotinamide Mononucleotide): A Controversial Choice
NMN boosts NAD levels but may neglect the root causes of NAD decline. Dr. Conlon did not assign a score, citing potential concerns over methyl donor depletion and its long-term efficacy. Some speculate this omission may reflect a potential conflict of interest, as Dr. Conlon’s company offers competing supplements.

Collagen: Skin Health Benefits
Collagen supports skin elasticity and reduces wrinkles, but high doses are needed for noticeable effects. Without broader cellular health improvements, its benefits are limited. Collagen received a moderate score of 6/10.

Nitric Oxide Lozenges: Cardiovascular Support with Caveats
Nitric oxide, a vasodilator, improves blood flow and supports cardiovascular health. However, its short half-life and the limited evidence supporting supplementation efficacy resulted in a score of 5/10.

Athletic Greens (AG1): Convenience at a Cost
AG1 provides a wide range of nutrients in a convenient format, particularly for those with poor diets. However, it is expensive, and individuals with balanced diets may not need it. Like NMN, AG1 was not assigned a specific score.

Final Thoughts

This analysis provides valuable insights into the benefits and drawbacks of popular supplements aimed at slowing the aging process. For a deeper understanding and additional details, viewers are encouraged to watch the full review.

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