These 2 OTC Supplements Reversed Cognitive Decline

A Game Changer for Brain Health

Author

My Longevity Experiment
November 15, 2024

The Role of Glycine & N-Acetylcysteine in Combating Age-Related Cognitive Decline

A groundbreaking study published in the journal Antioxidants sheds light on how a combination of two Over the Counter (OTC) supplements, glycine and N-acetylcysteine (NAC), may slow or even reverse cognitive decline associated with aging. Researchers at Baylor College of Medicine have been exploring the biological processes underlying this decline and developing nutritional strategies to promote healthier brain aging.

Understanding Age-Related Cognitive Decline

Cognitive decline is a natural part of aging, but scientists aim to mitigate its impact to help individuals maintain optimal brain function throughout their lives. At Baylor College of Medicine, researchers are dedicated to uncovering the mechanisms driving this decline and identifying interventions to support cognitive health.

Glycine and N-Acetylcysteine: The GlyNAC Formula

The study in Antioxidants demonstrated that supplementing with GlyNAC, a combination of glycine and NAC, which are precursors to the antioxidant glutathione, significantly improved or reversed age-related cognitive decline in older mice. Additionally, GlyNAC supplementation addressed various defects associated with brain aging.

Dr. Rajagopal Sekhar, the study's senior author and a professor of medicine, endocrinology, diabetes, and metabolism at Baylor College of Medicine, noted the relevance of these findings to humans. He stated, "Our work provides an understanding of how age-associated cognitive decline in older humans is linked to glutathione deficiency, increased oxidative stress, mitochondrial dysfunction, abnormal glucose metabolism, insulin resistance, inflammation, and low levels of neurotrophic or neuron-supporting factors, and that supplementing GlyNAC reverses these defects and improves cognition."

Exploring Cognitive Decline in Aging Mice

Human studies often assess whole-body outcomes, limiting direct insights into brain-specific changes. This study focused on naturally aging mice, allowing researchers to investigate brain defects that contribute to cognitive decline without introducing artificial gene mutations. The researchers emphasized that aging itself is the most significant risk factor for Alzheimer’s disease, making these findings particularly impactful.

Study Design: Evaluating the Effects of GlyNAC

The researchers divided the mice into three groups: young mice, naturally aged mice receiving a regular diet, and naturally aged mice receiving a GlyNAC-supplemented diet. At 90 weeks old, comparable to 70 years in humans, the aged mice were evaluated for cognitive abilities, such as maze navigation. After eight weeks on their respective diets, cognitive tests were repeated, and the brains of the mice were analyzed for defects previously linked to cognitive impairment.

Dr. Sekhar highlighted the study's results: “Compared to young mice, old mice had cognitive impairment and many brain abnormalities such as glutathione deficiency, increased oxidative stress, impaired mitochondrial function, elevated inflammation, genomic damage, and lower levels of brain-supporting factors. Importantly, we found evidence that there was a shortage of transporters responsible for moving glucose, the main fuel for the brain. This problem gets worse because the mitochondria, the engines that burn glucose to provide energy, were also not working well in the brain. The brain requires a very large amount of energy for its function, and these defects suggest that the aging brain is starved of energy, which could result in cognitive decline.”

Key Findings: GlyNAC’s Impact on Brain Aging

The study revealed that GlyNAC supplementation reversed many age-related brain defects in older mice. These included restoring glutathione levels, improving mitochondrial function, enhancing glucose transport to the brain, and reducing oxidative stress, inflammation, and genomic damage. These changes were accompanied by notable cognitive improvements.

Dr. Sekhar stated, "It is really exciting to see so many improvements in the brain with GlyNAC supplementation, as it provides evidence that it may now be possible to improve brain health in aging. Going forward, we plan to conduct a larger randomized clinical trial in older people to study the effect of GlyNAC supplementation on improving cognitive and brain health in aging."

Previous Research Supports GlyNAC’s Benefits

Earlier studies by the same team demonstrated GlyNAC’s ability to improve biological defects in other organs, such as the heart, liver, and kidneys, and even extend lifespan in animals. A recent randomized clinical trial in older humans showed similar improvements in skeletal muscle, blood markers, and the reversal of aging hallmarks, further supporting GlyNAC's potential to promote overall health and longevity.

Implications for Alzheimer’s Disease and Cognitive Impairment

Dr. Sekhar concluded, "Our findings may also have implications for Alzheimer’s disease and mild cognitive impairment, because similar defects are also reported in these conditions. We are currently evaluating whether older people with mild cognitive impairment have glutathione deficiency compared to older people without a diagnosis of cognitive impairment."

Commercial Considerations

The Baylor College of Medicine holds the patent for GlyNAC, which has been licensed to Nestlé Health Science. The supplement is marketed in the United States under the name Celltrient Cellular Protect.

This research underscores the potential of GlyNAC supplementation as a promising intervention to support brain health and combat age-related cognitive decline, with far-reaching implications for aging populations worldwide.

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